We are visionaries.
We believe that the enormous challenge of making cancer curable can be overcome only with a different approach.
Our approach is entirely empirical, we don’t take anything for granted. We re-define the challenge itself, and combine expertise from multiple disciplines into new methods and tools.
Nucleix is a liquid biopsy company revolutionizing cancer treatment with earlier disease detection, at a time when intervention can bring the greatest impact for patients. Leveraging PCR-based epigenetics, our pioneering testing approach uses methylation-based identification for early-stage and recurring cancer detection. Our non-invasive EpiCheck® platform delivers highly accurate and sensitive results, all while providing a seamless testing option for patients and the healthcare system. Our global team operates from San Diego, United States as well as from Rehovot Israel.
Chris Hibberd, B.Sc., MBA Executive Chairman & CEO
Chris Hibberd, B.Sc., MBA
A proven team builder with over 20 years of experience in working with innovative teams to identify, create and build high value medical device products and biotech discovery technologies. Co-Founded and built Astute Medical, an innovative medical technology discovery and diagnostic company. Built an impressive team, secured VC funding, negotiated debt financing, built a product pipeline, launched the 1st FDA cleared product for Acute Kidney Injury risk and negotiated numerous global collaborations. One of the collaborators, bioMérieux, acquired Astute Medical in April 2018. Prior to Biosite’s $1.7B acquisition in 2007, he led a productive business development and strategic planning group and co-founded Biosite Discovery to leverage a world class antibody capability. After securing an MBA from the University of Western Ontario in Canada, he worked for 5 years as a management consultant with the Boston Consulting Group in the US, Canada, Mexico and Spain. Graduated with a Chemical Engineering degree from the University of Toronto.
Danny Frumkin, PhD VP Biochemistry
Danny Frumkin, PhD
As co-founder of Nucleix, Danny brings extensive experience and know-how in molecular biology, cancer genetics, and DNA biochemistry. Alongside Adam, he co-developed a non-invasive high-resolution method for determination of cell lineage based on analysis of somatic DNA mutations, resulting in the establishment of an international lineage center at the Weizmann Institute. Danny is the author of 11 scientific papers and co-inventor of several patents. Danny holds an Ph.D. in Life Sciences from the Weizmann Institute, as well as an B.Sc. in Medical Sciences from Tel-Aviv University.
Adam Wasserstrom, PhD VP Bioinformatics
Adam Wasserstrom, PhD
Bringing deep knowledge in computer science, bioinformatics, and statistical analysis, Adam co-founded Nucleix and has been an instrumental part of building the company from its inception. Together with Danny, he co-developed a non-invasive high-resolution method for determination of cell lineage based on analysis of somatic DNA mutations, resulting in the establishment of an international lineage center at the Weizmann Institute. Adam is the author of 9 scientific papers and co-inventor of several patents. Adam holds a Ph.D. in Life Sciences from the Weizmann Institute, and a B.A in Computer Sciences cum laude and Music from Tel-Aviv University.
Eran Bram, PhD VP Product Development
Eran Bram, PhD
Eran is an experienced R&D manager with specific focus on the development and productization of In-vitro molecular diagnostics assays and software. Previously, Eran served as a Sr. Scientist and Manager at Asuragen Inc., and was the founder and CSO at Piercell Bio, Ltd. Eran is an author of 11 scientific papers, an inventor of 2 patents and has served as PI on multiple SBIR grants. Eran holds a PhD in Life Sciences from the Technion, Israel Institute of Technology and has completed his postdoctoral fellowship in biological engineering at MIT.
Aharona Shuali, MD, MBA VP Medical
Aharona Shuali, MD, MBA
Aharona has over 10 years of experience in development and commercialization of oncology-targeted products in the pharmaceutical and medical device industries. Prior to Nucleix, Aharona served as Medical Manager at Roche Pharmaceutical Israel, Medical Director at AstraZeneca Israel, Senior Global Product Manager in Philips Healthcare and VP Oncology at Insightec. Aharona holds an MD from the Hebrew University, and an MBA from Tel Aviv University.
Shmuel Adler, B.Pharm, MSc VP Regulation, Clinical and QA
Shmuel Adler, B.Pharm, MSc
Shmulik carries over 15 years of experience in successfully leading the development and overseeing clinical trials, regulatory affairs, and quality assurance for companies. Shmulik has led many global FDA regulated multicenter studies. Shmulik is a licensed Pharmacist from the Hebrew University and has an M.Sc. in Pharmacology and Physiology from Tel Aviv University
Ricardo A.J. ten Velden VP Sales & Marketing
Ricardo A.J. ten Velden
Ricardo has over 30 years of experience in business development and sales & marketing. He achieved a sustained record of success in the Life Sciences industry e.g. innovative (lifestyle) prescription drugs, generics, biologics, biosimilars, and medical devices. He started his career in Pharmaceuticals and later transitioned to molecular diagnostics. Before joining Nucleix he served as the Director Sales & Marketing EMEA of MDxHealth (ENX:MDXH), a multinational healthcare company that provides actionable genomic information to personalize the diagnosis and treatment of cancer. Prior to this he was commercial leader for international markets in companies such as Avery Dennison, Merck Sharp & Dohme and Organon (AkzoNobel). For Organon he worked more than six years as an expat in Italy. Back in the Netherlands he set up the Benelux subsidiary of Hikma Pharmaceuticals (LON:HIK). Ricardo studied law at VU University Amsterdam and marketing at the Netherlands Institute of Marketing.
Shay Shemesh, B.A, MBAVice President, Finance
Shay Shemesh, B.A, MBA
Shay is responsible for managing Nucleix's financial, accounting and operations activities with over 13 years' experience. Prior to joining Nucleix, Shay served as Director of Finance and Operation in ,MultiPhy Ltd, a pioneer and leading provider of ultra-high speed connectivity solutions for next generation hyper-scale Data Centers. Prior to MultiPhy, Shay served as CFO of publicly traded Bioview, a leader in the laboratory equipment market for cancer screening. Prior to joining BioView, Shay served as a Senior Auditor at PricewaterhouseCoopers (PwC) in Tel-Aviv where he was responsible for a wide range of clients including, publicly traded companies, both on the NASDAQ and the Tel-Aviv Stock Exchange (TASE) and Venture Capital firms. Shay is a Certified Public Accountant and holds a BA in Economics and Accounting from the Hebrew University and an MBA from Tel Aviv University.
Todd Myers, B.Sc.Chief Financial Officer
Todd Myers, B.Sc.
Todd has over 25 years of experience in both public and private companies, primarily in the life science and healthcare fields. As the CFO of multiple companies, he has negotiated with investors and strategic partners to raise over $320 million in capital through the issuance of equity and debt, and the out-licensing of technology. Prior to joining Nucleix, Todd was the chief financial officer of Astute Medical, which was acquired in 2018 by bioMerieux, a multinational biotechnology company headquartered in France. While with Astute, he played a lead role in raising equity and debt capital to support the research, clinical/product development and commercialization of NephroCheck®, the first FDA cleared diagnostic for acute kidney injury, as well a lead role in Astute’s sales process. He was responsible for all finance and general and administrative activities at both Astute and its wholly-owned subsidiary in Europe. Prior to Astute, Todd was the chief financial officer at SGX Pharmaceuticals, a publicly-traded company focused on the discovery, development and commercialization of innovative cancer therapeutics, until its acquisition by Eli Lilly & Company. He was also the Director of Finance at CombiChem, Inc., a publicly-traded computational drug discovery company, which was acquired by DuPont Pharmaceuticals. Todd began his career as an auditor in the San Diego office of Ernst & Young and obtained a B.S. in accounting from the University of Illinois, Champaign-Urbana.
Eyal Miller, B.Sc., MBAGM EMEA
Eyal Miller, B.Sc., MBA
Eyal has 25 years experience of proven success stories across Medical Devices, IVD and Pharma arena. Previously he was VP & Head of the Healthcare Division at Stratasys ( NASDAQ: SSYS). Eyal successfully launched a cutting edge Technology enabling Hospitals and MedTech companies with the first in class 3D Anatomical Models. Prior to joining Stratasys, Eyal was the CEO and Board member at Common Sense, an IVD Company within women's Healthcare. during his tenure, Eyal has led the company into acquisition by an Asian Venture Capital. Eyal holds a Bachler degree from Ben Gurion University in Chemistry as well as MBA and MA in Law studies.
OrbiMed Israel Limited Partnership
OrbiMed Israel Limited Partnership
OrbiMed have been investing globally for over 20 years across the healthcare industry: from early-stage private companies to large multinational corporations. Investments are made in one of three strategies: public equity, private equity, and royalty opportunities. Their team of over 80 distinguished scientific, medical, investment and other professionals manages over $13 billion across public and private company investments worldwide.
Zohar Zisapel
Zohar Zisapel
Zohar Zisapel is a successful Israeli entrepreneur in Israel’s advanced high-tech industry.
OCI Investments Corp.
OCI Investments Corp.
Oci Investments Corp. filed as a Foreign For-Profit Corporation in the State of Texas.
Aurum Ventures M.K.I. Ltd
Aurum Ventures M.K.I. Ltd
Aurum Ventures MKI provides value added growth capital to exceptional entrepreneurs in the healthcare area. While we focus on investing in unique, cutting edge technologies that will mature into successful business companies, our investments reflect our own values, so we prefer investing in companies that, through their sound commercial propositions, also contribute to the well-being of mankind. Our team is comprised of senior and experienced hands-on executives who work actively with the portfolio companies in enhancing their strategic and execution capabilities. We typically take a long-term approach, understanding that ventures in the life sciences and healthcare areas take time to mature and be successful.
DSC Investment
DSC Investment
A venture capital firm for innovative entrepreneurs leading paradigm shifts.
Chris Hibberd, Executive Chairman & CEO
Chris Hibberd, Executive Chairman & CEO
A proven team builder with over 20 years of experience in working with innovative teams to identify, create and build high value medical device products and biotech discovery technologies. Co-Founded and built Astute Medical, an innovative medical technology discovery and diagnostic company. Built an impressive team, secured VC funding, negotiated debt financing, built a product pipeline, launched the 1st FDA cleared product for Acute Kidney Injury risk and negotiated numerous global collaborations. One of the collaborators, bioMérieux, acquired Astute Medical in April 2018. Prior to Biosite’s $1.7B acquisition in 2007, he led a productive business development and strategic planning group and co-founded Biosite Discovery to leverage a world class antibody capability. After securing an MBA from the University of Western Ontario in Canada, he worked for 5 years as a management consultant with the Boston Consulting Group in the US, Canada, Mexico and Spain. Graduated with a Chemical Engineering degree from the University of Toronto.
Dr. Heiner Dreismann
Dr. Heiner Dreismann
Dr. Dreismann, is a seasoned executive with more than 30 years of experience in the health care industry, and is regarded as a pioneer in the early adoption of the polymerase chain reaction (PCR) technique, one of the most ubiquitous technologies in molecular biology and genetics research today. He had a successful career at the Roche Group from 1985 to 2006 where he held several senior positions, including President and CEO, Roche Molecular Systems, Head of Global Business Development, Roche Diagnostics and Member of Roche’s Global Diagnostic Executive Committee. Dr. Dreismann currently serves on the boards of several public and private health care companies. He earned a master of science degree in biology and his doctor of philosophy degree in microbiology/molecular biology (summa cum laude) from Westfaelische Wilhelms University (The University of Munster) in Germany.
Erez Chimovits
Erez Chimovits
Erez Chimovits is a Partner at OrbiMed. Erez has 14 years of operational experience, including 10 years of senior managerial experience in public companies. Prior to joining OrbiMed Erez was the CEO of NasVax (TASE:NSVX). NasVax acquired Protea and struck agreements with GlaxoSmithKline and Novartis. Previously, Erez spent more than seven years with Compugen (Nasdaq:CGEN), as President, Compugen USA Inc. and Executive VP, Commercial Operations. At Compugen, he had responsibility for more than 100 people and led multiple transactions including J&J, Novartis, Teva, Abbott, Medarex and others. Erez earned his M.B.A., M.Sc. in Microbiology and his B.Sc. from Tel Aviv University.
Dr. Thomas Buchholz
Dr. Thomas Buchholz
Dr. Buchholz is a corporate SVP and Medical Director of Scripps MD Anderson Cancer Center in San Diego. His responsibilities include oversight of the clinical care of cancer patients, the development of clinical and translational research activities, and academic collaborations with MD Anderson. He also continues a radiation oncology practice focused on breast cancer. He previously has held a variety of clinical, research, academic and administrative leadership positions with MD Anderson Cancer Center in Houston, including division head and department chair of radiation oncology, Provost ad-interim, and Executive Vice President/Physician-in-Chief, during which he was responsible for all aspects of clinical care and operations of MD Anderson’s hospital and ambulatory clinics. Nationally he has held a variety of leadership roles including two terms as co-chair of the NCI's Breast Cancer Steering Committee. His academic efforts and efforts to improve the patient experience have been recognized with several national awards. Dr. Buchholz earned his medical degree from Tufts University School of Medicine in Boston. He completed his residency and a radiobiology research fellowship at the University of Washington Medical Center in Seattle. He is board certified by the American Board of Radiology and the National Board of Medical Examiners. He earned his bachelor’s degree in philosophy from Bucknell University in Lewisburg, Pa, and currently serves on Bucknell's Board of Trustees.
Ilan Lior
Ilan Lior
Ilan Lior serves as the general counsel of Aurum Ventures M.K.I. Ltd. and is member of Aurum’s senior management team. He also serves on various boards of Aurum’s portfolio companies. Prior to joining Aurum, Ilan was a partner in a boutique law firm where he headed the corporate and commercial practice group. Ilan is a member of the Israeli bar and holds LLW and a BA (eco), both from the Tel Aviv University.
Prof. Eric A. Klein
Prof. Eric A. Klein
Eric A. Klein, MD, is the Chairman of the Glickman Urological & Kidney Institute and a staff member in the Taussig Cancer Institute at Cleveland Clinic. His clinical interests are cancers of the prostate, testis and kidney. For several years, including the current edition, Prof. Klein is listed in Best Doctors in America. Board-certified in urology, Prof. Klein is a frequent lecturer and visiting professor at numerous national and international universities. He was the National Medical Study Coordinator for the National Cancer Institute sponsored Selenium and Vitamin E Cancer Prevention Trial (SELECT). Prof. Klein is the editor of Urology and has been the recipient of numerous awards from the American Cancer Society, the University of Pittsburgh School of Medicine, and the Cleveland Clinic. Prof. Klein received his medical degree from University of Pittsburgh School of Medicine in Pennsylvania. He completed his residency in urology at Cleveland Clinic and a fellowship in urology at the Memorial Sloan Kettering Cancer Center in New York.
Prof. Fred Witjes
Prof. Fred Witjes
Fred Witjes is professor in oncological urology. His research interest is translational and clinical research in bladder, prostate and testicular cancer. He has many training and teaching activities. He is a member of several international societies, and he chairs, amongst others, the Dutch guidelines committee on bladder cancer and the EAU guidelines committee on metastatic and muscle-invasive bladder cancer. He is reviewer for many, and editor of several urological and oncological journals. He is involved in and leads many studies and projects which has resulted in many lectures and over 550 (peer reviewed) publications, reviews and bookchapters.
Dr. Barton Grossman
Dr. Barton Grossman
Part-time Professor in the Dept. of Urology M.D. Anderson Cancer Center. Dr. Grossman was awarded his medical degree from Temple University. He then completed a residency in Urology at the University of Michigan. He obtained additional training in a clinical and research fellowship at Memorial Sloan-Kettering Cancer Center and returned to the University of Michigan where he rose to Professor. In 1994, he joined the faculty of The University of Texas M. D. Anderson Cancer Center where he is Professor and Deputy Chairman of the Department of Urology. Dr. Grossman has numerous publications and continues to have an active research laboratory.
Dr. Seth Lerner
Dr. Seth Lerner
Seth P. Lerner, MD, is Professor of Urology and holds the Beth and Dave Swalm Chair in Urologic Oncology, in the Scott Department of Urology, Baylor College of Medicine. He is Director of Urologic Oncology and the Multidisciplinary Bladder Cancer Program and Vice-Chair for Faculty Affairs. His research interests include use of selective estrogen receptor modulators for treatment of bladder cancer, gene therapy, surgical quality and outcomes and integrated genomic characterization of bladder cancer. He has 27 years of experience as a clinical investigator for both NCI and industry funded clinical trials. He is chair of the Local Bladder Cancer committee of SWOG, co-chair of the GU Steering Committee for CTEP and co-chaired the Analysis Working Group of The Cancer Genome Atlas Project for muscle invasive bladder cancer.
Prof. Maria J. Ribal
Prof. Maria J. Ribal
Maria J. Ribal received her medical degree in 1994, followed by her PhD in 2002, both at the University of Barcelona. After 5 years residency in urology at the University Hospital Clinic in Barcelona, she became a member of the Spanish Board of Urology in 1999. She did a research Fellowship with an Investigation Grant at the Hospital Clinic in 2000-2001. She attended as Visiting Clinician at Mayo Clinic in Rochester (USA) in 2002. Fellow in Laparoscopic Surgery at the University College London Hospital (UCLH) from June till December 2006. She has been member at the Oncology Unit of the Department of Urology at Fundacio Puigvert (2002-2005). Since February 2005, she is member of the Department of Urology at the University Hospital Clinic of Barcelona. Currently, she is Associated Professor of Surgery at the University of Barcelona. From December 2011 she is the Head of the Multidisciplinary Unit of Uro- Oncology at Hospital Clinic. Her main interests include urologic oncology, major oncologic surgery, laparoscopic surgery and transplantation and genetic research of urological tumors. She is the author of 53 national and 22 international publications, 10 book chapters, and 195 invited lectures at conferences and courses. She is an active member of European Association of Urology: Member of the Muscle Invasive and Metastatic Bladder Cancer Guidelines Group of the European Association of Urology (EAU) since 2006, Member of the ESUT Working group from European Association of Urology since 2010. Board member of the EUSP Office of the European Association of Urology since April 2012. In 2009, during the EAU Annual Meeting held in Stockholm, she received the Crystal Matula award.
Dr. Peter Mazzone
Dr. Peter Mazzone
Peter Mazzone is a pulmonologist at the Cleveland Clinic where he directs the Lung Cancer Program for the Respiratory Institute and the Lung Cancer Screening Program for the hospital system. His clinical interests include prevention, screening, nodule management, lung cancer diagnosis, staging, and characterization. He has research interests in each of these clinical areas, including work on the development of molecular biomarkers for lung cancer detection. He has served in leadership positions within Chest and the American Thoracic Society which have allowed him to lead policy development projects related to quality metrics for the evaluation of lung cancer, components necessary for high-quality lung cancer screening, and the clinical application of molecular biomarkers for lung cancer detection. He has also been an active member of evidence-based guidelines related to lung cancer screening and lung nodule management.
Prof. Mina Gaga
Prof. Mina Gaga
Dr Mina Gaga MD, PhD is Director of the 7th Respiratory Medicine Dept and Asthma Centre at Athens Chest Hospital "Sotiria". The hospital is a center of excellence for lung disease, catering to more than 50000 inpatient and 100000 outpatient and emergency patient visits. Among those, more than 2000 new lung cancer patients are diagnosed, staged and treated per year. Dr Gaga is much involved in clinical work, focusing particularly in lung cancer and asthma, in clinical research and in medical education programs. She has been actively involved as PI in multiple clinical trials, has been active internationally in guideline development for screening in lung cancer and severe asthma and has published extensively in these research areas. She has moreover served as Director of Learning Resources of the ERS School, Secretary of the European Board of Accreditation in Pneumology (EBAP), Secretary General and president of the ERS, serves in the HERMES examination committee and the European Αdult and Thoracic Oncology HERMES Diplomas.
Prof. John Field
Prof. John Field
Professor John Field, PhD, FRCPath has a Personal Clinical Chair in Molecular Oncology at the University of Liverpool. He is a Visiting Professor at University College London, holds the post of Director of Research of the Roy Castle Lung Cancer Research Programme. He is the Chief Investigator for the UK Lung Cancer Screening Trial (UKLS). Previous Chair of the IASLC Screening Prevention & Early Detection Committee and he formed IASLC Strategic Screening Advisory Group. Member of the ILCCO Steering Committee He was presented with the IASLC Joseph Cullen Award at the WCLC 2011, in recognition of lifetime scientific achievements in lung cancer prevention research. He is Chair of the IASLC Strategic Screening Advisory Committee. He is the principle investigator of the Liverpool Lung Project, a molecular- epidemiological study into the early detection of lung cancer (~12,000 recruited), funded by the Roy Castle Lung Cancer Foundation. The UKLS and the LLP form part of the NCRI Lung Cancer portfolio. He is also a Partner in the FP7 CURELUNG and LCAOS projects and the NIH GWAS non-smokers and the Oncoarray studies. He is also heavily involved in the identification of molecular diagnostic markers in lung and head & neck cancers. His research funding has been provided mainly by the RCF, NWCRF, MRC, CRUK, EU, NIH and the HTA. Professor Field is the author of over 270 international (peer reviewed) papers in his area of expertise and has given more than 350 presentations at medical and scientific conferences around the world.
Prof. Martin C. Tammemägi
Prof. Martin C. Tammemägi
Tammemägi has MSc and PhD degrees in Epidemiology from the University of Toronto. He served as co-investigator in the US NIH NCI sponsored National Lung Screening Trial. Currently, he is Professor of Epidemiology in the Department of Health Sciences at Brock University in Canada and is Scientific Lead on Cancer Care Ontario’s Lung Cancer Screening Pilot for People at High Risk. His research has a focus on lung cancer screening, lung cancer risk prediction modelling and prediction modelling of which pulmonary nodules detected on computed tomography screening are cancer. His lung cancer risk prediction models, including the PLCOm2012 (Tammemagi MC et al. NEJM 2013) and his nodule malignancy probability model (PanCan model; McWilliams A, Tammemagi M, et al. NEJM 2013) have received widespread validation and implementation. Regarding programmatic public health implementation of lung cancer screening, he has a strong research and applied interest in indicators and measures of screening performance through the different phases of lung cancer screening programs.
Israel Innovation Authority
Israel Innovation Authority
The Office of the Chief Scientist was established in 1974. It was renamed the Israel Innovation Authority in 2016. The main aim of the department is to increase economic empowerment within the civilian sector of the Israeli economy. Main activities include the funding of research and policy-making within its sphere of influence. The development and prominence of the OCS was further strengthened by the development of the Venture Capital industry within Israel in the 1990s. A variety of ongoing support programs offered by the Authority provide financial and developmental resources to entrepreneurs and companies of all sizes and stages performing industrial R&D research within Israel.
HORIZON 2020
HORIZON 2020
Horizon 2020 is the biggest EU Research and Innovation programme ever with nearly €80 billion of funding available over 7 years (2014 to 2020) in addition to the private investment that this money will attract. It promises more breakthroughs, discoveries and world-firsts by taking great ideas from the lab to the market. Horizon 2020 is the financial instrument implementing the Innovation Union, a Europe 2020 flagship initiative aimed at securing Europe's global competitiveness. Seen as a means to drive economic growth and create jobs, Horizon 2020 has the political backing of Europe’s leaders and the Members of the European Parliament. They agreed that research is an investment in our future and so put it at the heart of the EU’s blueprint for smart, sustainable and inclusive growth and jobs. By coupling research and innovation, Horizon 2020 is helping to achieve this with its emphasis on excellent science, industrial leadership and tackling societal challenges. The goal is to ensure Europe produces world-class science, removes barriers to innovation and makes it easier for the public and private sectors to work together in delivering innovation.
At Nucleix, we strongly view each employee as a partner who plays a critical role in advancing the company and its successes. The current team has a passion and drive for advancing innovation and science to change the landscape of how we currently detect patients with cancer. We’re always looking for exceptional individuals that share that dedication to join our team. If that’s you, please send your resume to info@nucleix.com
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